All stagesStage 5 of 8

Clinical validation

Does it work, measured properly?

Usability studies, clinical trials, and outcome measurement against a defined endpoint.

Open technical problems

What is still hard here

Unsolved engineering problems at this stage, each linked to work documenting the difficulty.

Technical problem
Aligning a 3D model to the patient on the table

An augmented overlay is only useful if it sits exactly where the anatomy is. Registration has to survive patient movement, soft-tissue shift, and a surgeon's changing viewpoint, and the error budget is millimetres.

ARMRCross-specialty
GlobalOpen problem
Technical problem
Knowing whether an in-headset score means anything

Headsets record rich data — gaze, movement, timing — and it is tempting to treat it as assessment. Establishing that those numbers correspond to real clinical ability is a separate and harder task.

VRARCross-specialty
GlobalOpen problem
Technical problem
Blinding and sham control in VR trials

A participant inside a headset knows whether the experience is therapeutic, so convincing placebo conditions and masking are hard to build. Trials often settle for blinding only the analysts, which leaves room for expectation effects.

VRClinical researchCross-specialty
GlobalOpen problem
Source reviewedAI-assisted
Technical problem
No agreed dose for a VR therapy

Session length, weekly frequency and total course vary widely between VR trials, and the best-performing settings differ by outcome and population. Without a standard dose, studies are hard to compare and a product's labelled regimen is hard to justify.

VRRehabilitationNeurology
GlobalOpen problem
Source reviewedAI-assisted
Technical problem
Showing benefit that outlasts the headset

Many VR studies measure change during or just after exposure. Evidence that effects persist weeks later, especially for chronic conditions, is thinner and inconsistent, which limits clinical and payer confidence.

VRPain management
GlobalOpen problem
Source reviewedAI-assisted
Problems

6 records at this stage

Clinical problem
Pain and fear during procedures in children

Children undergoing short but painful procedures experience distress that sedation cannot always address, and fear compounds the pain itself.

VRPain managementNursing
GlobalActive challenge
Clinical problem
Severe acute pain where drug options are limited

In crises such as vaso-occlusive episodes, pain is severe and escalating analgesia carries its own risks, leaving a gap for non-pharmacological adjuncts.

VRPain management
GlobalActive challenge
Clinical problem
How much realism a scenario actually needs

Higher fidelity costs more and is assumed to teach better, but which cues change behaviour — and which are decoration — is rarely tested.

VRMedical educationHuman factors
GlobalActive challenge
Clinical problem
Regaining arm function after stroke

Recovery needs many repetitions of movement that is difficult, tiring, and unrewarding to perform, so adherence and intensity both suffer.

VRRehabilitation
GlobalActive challenge
Clinical problem
Translating motor-learning research into therapy

Findings about how movement is relearned are well established in the laboratory and slow to reach the treatment room.

VRHapticsRehabilitationClinical research
GlobalActive challenge
Solutions

2 records at this stage

Surgical training platform
PrecisionOS

A VR and mobile training platform focused on surgical skills, case practice, feedback, and institution-level learning insights.

VROrthopedicsSurgery
Canada / GlobalCommercial
Source reviewed
Prescription VR system
RelieVRx

A prescription-use immersive VR system providing adjunctive, skills-based treatment for adults with chronic lower-back pain.

VRPain management
United StatesCommercial medical device
Source reviewed
Organizations

7 records at this stage

Healthcare technology company
AppliedVR

Developer of immersive therapeutics, including the prescription-use RelieVRx system for chronic lower-back pain.

VRPain managementBehavioral health
United StatesCommercial
Source reviewed
Immersive training company
Osso VR

Healthcare procedural-skills training platform offering VR scenarios, assessment, collaboration, and learning-management tools.

VRNursingSurgery
United StatesCommercial
Source reviewed
Immersive therapeutics company
Oxford VR

Developer of VR-delivered psychological treatments guided by a virtual coach, targeting conditions ranging from anxiety to psychosis.

VRBehavioral health
United KingdomCommercial
Immersive therapy company
Floreo

VR therapy platform delivering structured social and communication practice for neurodiverse learners, delivered on headsets, phones, or a browser.

VRBehavioral healthNeurodiversity
United StatesCommercial
Source reviewed
Immersive therapeutics company
firsthand Technology

Developer of biosensor-enabled VR environments for procedural and chronic pain, including a biofeedback experience driven by heart-rate monitoring.

VRPain managementBehavioral health
United StatesCommercial
Source reviewed
Neurotherapeutics company
MindMaze Therapeutics

Developer of neurorehabilitation systems combining immersive software, smart peripherals, and motion analytics for recovery after stroke and other neurological conditions.

VRScreen-basedRehabilitationNeurology
SwitzerlandCommercial
Source reviewed
Digital therapeutics company
Limbix

Developer of evidence-based digital therapeutics for adolescent mental health, including the SparkRx programme. Acquired by Big Health in July 2023.

VRScreen-basedBehavioral health
United StatesAcquired
AcquiredSource reviewed
Evidence

1 record at this stage

Stuck at this stage?Ask the members who work here — questions go to the people who can help.
See questionsAsk